Does Theacrine (Teacrine) Work?
Theacrine (as TeaCrine™) is a remarkably effective and natural energy booster that offers all the benefits of caffeine (plus a few more) with none of its drawbacks.
Theacrine – What is it?
Theacrine is an alkaloid chemically similar to caffeine, but found in the tropical copoasu tree and a Chinese tea made from the kucha plant, rather than coffee beans.
Theacrine is actually synthesized from caffeine in these plants by what is thought to be a three stage process that modifies the molecule into a new form (1) that keeps its energy and attention boosting properties, eliminates nervousness, and adds fantastic health benefits.
Works Well with Caffeine
We all enjoy our morning coffee, and some of us may enjoy it a bit too much. You end up jittery and distracted instead of focused and alert.
Theacrine can help.
Research published in the Journal of Caffeine Research found that when people consumed caffeine and theacrine together – they interacted in an interesting way.
The findings indicate that caffeine increases the bioavailability of theacrine to reduce the dose of both substances needed to improve energy. This means theacrine makes less caffeine feel like more (2).
So you’ll be less likely to experience adverse affects from over-indulging, like:
- Heart palpitations
A randomized, double-blind, placebo controlled study (the gold standard of research) found that theacrine can significantly approve alertness levels – and they used brain waves measurements (EEG) to confirm it!
Researchers assessed whether an energy supplement containing theacrine could improve cerebral-cortical activation (attention) and mental performance during an attention-switching task participants were required to complete.
There were 24 participants and all were right-handed, had low to moderate daily caffeine consumption, and were between 18 and 35 years old.
The EEG data showed that supplementation caused a measurable improvement in both brain activity and task performance in the participants who received the theacrine energy supplement instead of a placebo (3).
Non-Habit Forming and Reduces Cholesterol
Unlike caffeine, theacrine isn’t habit-forming and won’t increase your blood pressure, raising your risk of cardiovascular disease.
In a study of sixty men and women taking a daily dose of up to 300 mg of theacrine daily or a placebo for two months, there was no sign of habituation. This means the test subjects didn’t build up a resistance to theacrine, requiring a higher dose to get the same benefit (4).
They also found that energy, focus, concentration, anxiety, motivation to exercise, and mood remained stable throughout the eight week study. And while body composition didn’t change there was a reduction in total cholesterol and importantly – it reduced unhealthy LDL cholesterol levels (4).
Theacrine Improves Mood
Dopamine is associated with feelings of happiness, contentment, motivation, and focus. It’s involved in many brain pathways and plays a critical role in functions like movement, sleep, learning, mood, memory, and attention (5).
So, it’s obviously a key component in health.
Low levels have been associated with depression and even schizophrenia. While testing if theacrine affects dopamine in humans might be unethical, an animal study has found that theacrine can potentially raise dopamine levels in the brain (6).
The rats were injected with theacrine and then examined to determine what effect it had on dopamine levels and locomotor activity; what researchers found (6) was that:
- Theacrine increased dopamine levels
- Increased locomotor activity (more energy)
- The animals didn’t develop a resistance to it after chronic exposure
The findings also indicate that theacrine increased activity in the region of the brain associated with pleasure and reward (6).
Theacrine may be the answer to low energy and mood for some people. If you enjoy drinking coffee; theacrine plays well with caffeine and the effects of one compliment the other.
It can reduce cholesterol, may increase dopamine levels, and isn’t habit-forming.
Studies have also shown that it can measurably improve focus and performance during activities that require mental effort.
Next Level Superfoods Multivitamin
Alpha Wolf Nutrition is proud to say that our Next Level Superfoods Multivitamin is the only multi on the market as of the time of this writing that offers Theacrine (Teacrine) in its formulation at 100mg per serving.
- Zheng, XQ; Ye, CX; Kato, M; Crozier, A; Ashihara, H (2002). “Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. Kucha)”. Phytochemistry. 60 (2): 129–34 – Link
- Hui He, Dejian Ma, Laura Brooks Crone, Matthew Butawan, Bernd Meibohm, Richard J. Bloomer, Charles R. Yates. Assessment of the Drug–Drug Interaction Potential Between Theacrine and Caffeine in Humans. Journal of Caffeine ResearchVol. 7, No. 3 – Link
- Marcos Daou, Julia Montagner Sassi, Matthew W. Miller & Adam M. Gonzalez (2019) Effects of a Multi-Ingredient Energy Supplement on Cognitive Performance and Cerebral-Cortical Activation, Journal of Dietary Supplements, 16:2, 129-140 – Link
- Lem Taylor, Petey Mumford, Mike Roberts, Sara Hayward, Jacy Mullins, Stacie Urbina, Colin Wilborn. Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. journal of the International Society of Sports Nutrition201613:2 – Link
- Drozak J, Bryła J. Dopamine: not just a neurotransmitter. Postepy Hig Med Dosw (Online). 2005;59:405-20 – Link
- Allison A. Feducciaa, et al. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors. Pharmacology Biochemistry and Behavior, Volume 102, Issue 2, August 2012, Pages 241-248 – Link